The Frustrations of Families: Henry Lynch, Heredity, and Cancer Control, 1962–1975

The Frustrations of Families: Henry Lynch, Heredity, and Cancer Control, 1962â•fi1975

سندرم Lynch -l و گزارش شش مورد بیمار مبتلا

More than two decades ago, Henry T. Lynch reported a hereditary non polyposis colorectal cancer (HNPCC) which is seen in some families with dominant mode of inheritance, also know as Lynch Syndrome type I and II. This form to hereditary colorectal cancer has an early age of onset (Less than 45 years) with predominantly proximal colonic involvement (type I) and can also be associated with extrac...

Family perspectives in lynch syndrome becoming a family at risk, patterns of communication and influence on relations

BACKGROUND A growing number of individuals are diagnosed with hereditary cancer. Though increased levels of anxiety and depression have been demonstrated around the time of genetic counselling, most individuals handle life at increased risk well. Data have, however, been collected on individual basis, which led us to focus on family perspectives of hereditary cancer. METHODS Lynch syndrome re...

Commentary (Pendergrass/Griffin): What the Physician Needs to Know About Lynch Syndrome: An Update

Dr. Henry Lynch was one of the first to recognize the existence of hereditary nonpolyposis colorectal cancer (HNPCC). While a relatively small percentage of families have this cancer predisposition syndrome, identification of individuals at risk is now standard of care and includes the potential for the prevention of colorectal cancer. Dr. Lynch and Jane Lynch have written a guide highlighting ...

Colorectal cancer survival advantage in MUTYH-associated polyposis and Lynch syndrome families.

The cardinal features of colorectal cancer in patients with the MUTYH-associated polyposis syndrome, featured in this editorial, are of very recent discovery and remain under review as new clinical phenotypes for these patients are still being identified. Importantly, its phenotype results from homozygosity of the MUTYH gene and, therefore, is inherited in an autosomal recessive pattern. In a m...